E’ stato istituito presso l’Università della Calabria, per l’anno accademico 2013/2014, il master di II livello in Terapia del dolore. La Regione Calabria, per la copertura di borse per la partecipazione di laureati a Master Universitari di II Livello, mette a disposizione 1 milione di euro disponibili a sportello. Verranno finanziati esclusivamente i master universitari di secondo livello in Italia (compresi quelli accreditati dall'ASFOR) e all'estero oltre ai dottorati esclusivamente all'estero. Per ogni informazione è possibile rivolgersi al seguente indirizzo e-mail: email@example.com oppure direttamente agli uffici dell'Assessorato alla Cultura della Regione Calabria a Catanzaro in Via Gioacchino da Fiore 86.
Excitotoxicity has been implicated in the retinal neuronal loss in several ocular pathologies including glaucoma. Dysfunction of Excitatory Amino Acid Transporters is often a key component of the cascade leading to excitotoxic cell death. In the retina, glutamate transport is mainly operated by the glial glutamate transporter GLAST and the neuronal transporter GLT-1. In this study we evaluated the expression of GLAST and GLT-1 in a rat model of acute glaucoma based on the transient increase of intraocular pressure (IOP) and characterized by high glutamate levels during the reperfusion that follows the ischemic event associated with raised IOP. No changes were reported in GLAST expression while, at neuronal level, a reduction of glutamate uptake and of transporter reversal-mediated glutamate release was observed in isolated retinal synaptosomes. This was accompanied by modulation of GLT-1 expression leading to the reduction of the canonical 65 kDa form and upregulation of a GLT-1-related 38 kDa protein. These results support a role for neuronal transporters in glutamate accumulation observed in the retina following an ischemic event and suggest the presence of a GLT-1 neuronal new alternative splice variant, induced in response to the detrimental stimulus.
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Impairment of Neuronal Glutamate Uptake and Modulation of the Glutamate Transporter GLT-1 Induced by Retinal Ischemia >>
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